Worried About My Kidneys

I found this on the web.
If you type in symptoms of kidney problems due to Ibuprofen, you’ll find many answers. Be careful who you listen to though.
Also, you can call “ask-a-nurse”, it’s free and very helpful.
I’m taking 600 mg, my doctor said make sure you eat with it and drink plenty of water. Don’t take it 30 minutes before you lie down.
I’m not a doctor Fred, be careful. Find a healthcenter in your area. They charge you by how much you make. There’s doctors there and you’ll get other medical care as well.
Just type in healthcenters in your state usually it\\\\\\\’s .org something good luck

What Are the Side Effects of Ibuprofen on the Kidneys?
Comments Mar 19, 2010 | By StJo
Photo Credit pill, pills image by laviniaparscuta from Fotolia.com Ibuprofen is an anti-inflammatory, pain-relieving and fever-reducing medicine in the group of drugs called nonsteroidal anti-inflammatory drugs–better known as NSAIDs. Like all NSAIDs, ibuprofen inhibits cyclooxygenase (COX) enzymes, thereby inhibiting the body\\\\\\\’s production of prostaglandins. Prostaglandins are produced by many body tissues and have a wide variety of local effects. Hence, blocking their production can cause an array of potential side effects, including gastrointestinal bleeding, visual disturbances, liver abnormalities, high blood pressure and variety of kidney disturbances. The severity of renal (kidney) side effects range from mild, reversible changes in water metabolism to permanent kidney failure.

Disturbances of Salt and Water Balance
The kidneys are the primary controllers of sodium, potassium and water balance in the body. Ibuprofen can disturb this balance by increasing the retention of salt and fluid in the kidney. This renal effect of ibuprofen can cause new onset high blood pressure, worsening of preexisting high blood pressure and edema (fluid accumulation in the extremities, especially the feet and ankles). People with heart failure and preexisting kidney disease are most at risk for this side effect of ibuprofen use.

Acute Kidney Failure
Ibuprofen can trigger acute renal failure in people with preexisting kidney disease, heart failure or serious liver disease. This occurs when the drug\\\\\\\’s inhibition of prostaglandin production causes a critical decrease in blood flow to the kidney. Immediate discontinuation of ibuprofen use in these situations typically results in recovery to the previous state of health.

Acute Tubulointerstitial Nephritis
The kidneys have two kinds of tissue: the filtering units (the glomeruli) and the kidney infrastructure (the tubulointerstitium). The tubulointerstitium includes the tiny tubes of the urine transport system plus other tissues that support the kidneys\\\\\\\’ structure and function. Acute tubulointerstitial nephritis (AIN) is an inflammatory condition of the kidneys\\\\\\\’ infrastructure tissues. Immune cells infiltrate the tissue and cause damage. NSAIDs–including ibuprofen–are a leading cause of AIN, which most commonly occurs after taking the drug for several months. With prompt discontinuation of the drug, the kidneys usually recover to their previous state of health.

Chronic Tubulointerstitial Nephritis
Daily use of ibuprofen over a period of three or more years may cause chronic tubulointersitial nephritis (CIN), a form of permanent kidney damage. Pain relievers (called analgesics) are a leading cause of CIN. CIN caused by NSAIDs (including ibuprofen) or other pain relievers is called analgesic nephropathy. The condition is characterized by permanent scarring and shrinkage of the kidneys, which progresses over time with continued use of the offending drug. Discontinuation of the drug will not reverse the kidney damage that has already been sustained, but it may prevent further progression of the disease. Analgesic nephropathy can lead renal failure and the need for kidney dialysis.

Nephrotic Syndrome
Ibuprofen and other NSAIDs have been implicated in a form of kidney disease called nephrotic syndrome. People with this disorder lose large amounts of protein in their urine, which causes a total body protein deficit and related edema. Nephrotic syndrome is caused by an abnormal reaction of the immune system that damages the kidneys\\\\\\\’ filtering units. NSAID-induced nephrotic syndrome can occur concomitantly with AIN.

References
Drugs.com: Ibuprofen, FDA monograph
Pfizer: Motrin product insert
\\\\\\\”Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy\\\\\\\”; David E Golan, Ph.D., et al., Editors; 2007
\\\\\\\”Harrison\\\\\\\’s Principles of Internal Medicine, 16th Edition\\\\\\\”; Anthony S. Fauci, M.D., et al., Editors; 2004
Patient UK: Interstitial nephritides and nephrotoxins
Article reviewed by Roman Tsivkin Last updated on: Mar 19, 2010

Read more: http://www.livestrong.com/article/95321-side-effects-ibuprofen-kidneys/#ixzz1ntb8gYT7