Lipitor is among the most popular medications used in America and Lipitor side effects may be significantly increased in people who use Lipitor and grapefruit juice together. Unfortunately the predictability of the Lipitor and grapefruit juice interaction is not enough to allow physicians to prescribe lower doses of Lipitor along with grapefruit juice to get predictable results. Most experts recommend using an alternative medication the statin class such as pravastatin or Crestor, but simvastatin also has a similar interaction with alcohol making it a poor choice as a substitute for Lipitor and grapefruit juice.
This whole Lipitor grapefruit juice interaction and the CYP 3A4 enzyme inhibition by grapefruit juice is widely misunderstood. This information has been given to patients suggesting that as long as they take the Lipitor in the evening and don’t drink grapefruit juice other than the morning they should be okay. The irreversible nature of the CYP 3A4 inhibition by grapefruit juice makes this not the case.
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