Methotrexate and alcohol have no specific drug interactions, although because of the potential serious side effects of methotrexate excess use of alcohol is considered a poor combination.

Methotrexate is an anti-metabolite and anti-folate drug. It is used to treat various different kinds of diseases like autoimmune diseases, Crohn’s disease, psoriasis, cancer, ankylosing spondylitis, rheumatoid arthritis, ectopic pregnancy and some neoplastic conditions. Methotrexate inhibits metabolism of folic acid in the human body. Methotrexate commonly causes significant side effects including suppression of bone marrow function that can lead to anemia and low white blood cell counts, so patients treated with methotrexate call for close medical attention. The combination of methotrexate and alcohol, especially if taken regularly can prove extremely dangerous. It may lead to worsening of the hematopoetic methotrexate side effects. Among methotrexate’s many other side effects are nausea and vomiting and hepatitis. Alcohol can also cause hepatotoxicity and cirrhosis, so the additive effects of methotrexate and alcohol may become problematic. If symptoms of hepatotoxicity such as jaundice or unexplained itching are noted immediate physician consultation is indicated.

In general the safest approach if you need to be on methotrexate is to avoid alcohol altogether, but certainly methotrexate and alcohol in excess or alcohol used regularly is not considered safe.   Consider learning more about methotrexate side effects because that is the specialty of


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