Prozac and alcohol have no specific drug interactions, although most physicians counsel against use of alcohol in depressed patients because of the central nervous system depressant effects of alcohol, and because it is more difficult to manage depression in patients who drink more than very moderate anounts.

Prozac is one of the trade names of fluoxetine. Prozac is usually used as an antidepressants and falls in the SSRI (selective serotonin re-uptake inhibitor) class of medications along with Celexa, Zoloft, Paxil, Lexapro and others. Prozac is also used to treat anxiety disorder, panic disorder, pre-menstrual syndrome, pre-menstrual dysphoric disorder, and obsessive compulsive disorder. Though in general there is no major interaction between Prozac and alcohol when these two are used together the efficacy of Prozac to help with the conditions it is being used to treat may be reduced.

The most commonly noted side-effects of Prozacs are sexual dysfunction, anorgasmia and reduced libido, along with nausea, irritability and tremor. These same symptoms are sometimes noted with alcohol use, and the side effects can be additive.

Though there is over-all no contradiction between prozac and alcohol, because of the potential reduction in the efficacy of Prozac, and because of the potential for increased Prozac side effects, most physicians counsel against the regular or excessive use of alcohol in patients taking Prozac.

The bottom line is that Prozac and alcohol in excess should be avoided.

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