Valtrex dosage varies a great deal based on which type of herpes virus is being treated. The herpes simplex family of viruses, both herpes simplex type 1 and herpes simplex type 2 are much more sensitive to low valtrex dosage therapy than the herpes zoster virus that causes chicken pox and shingles.
Valtrex is brand name for valaciclovir, a guanine analogue antiviral. Valtrex is a pro-drug of acyclovir; it is converted into acyclovir in the liver. Valtrex works by stopping virus from synthesizing DNA using viral DNA olymerase. It is used to prevent and treat herpes simplex, and the two manifestions of herpes zoster, chicken pox and shingles. Valtrex is not used for viral infections such as cold and flu becaue these viruses are not responsive to even high Valtrex dosage.
Valtrex dosage for the initial infection with genital herpes simplex virus is 1000 mg twice daily for 7-10 days. For recurrent episodes of genital herpes simplex Valtrex dosage is usually 500 mg twice daily for 3 days, or 1000 mg once daily for 5 days. For cold sores, the manifestation of oral herpes simplex just two doses of 2000 mg are given 12 hours apart. Valtrex dosage for HIV positive patients as a prevention of cold sores is 500mg twice a day, and for recurrent herpes simplex infections in HIV patients a Valtrex dosage of 1000 mg twice daily for 5-10 days is recommended. Valtrex dosage for shingles is 1000 mg three times daily for 7 days, and for children with chicken pox with normal immune systems the Valtrex dosage is 20 mg/kg every 8 hours for 5 days with a maximum dose of 1000 mg every eight hours.
Valtrex is primarily excreted through the kidney, so patients with markedly reduced renal function, usually considered a creatinie clearance of less than 29 ml/minute, may require Valtrex dosage adjustment. Fortunately Valtrex side effects are relatively uncommon at the recommended Valtrex dosages.
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